abstract：BACKGROUND:Current non-invasive methods of assessing disease activity in systemic lupus erythematosus (SLE) are of limited sensitivity and specificity. Testing includes acute phase markers, autoantibodies and complement levels. Although measurements of dsDNA antibodies and complement C3/C4 levels are routine, they rema...

journal_title：Lupus

authors： Adhya Z,El Anbari M,Anwar S,Mortimer A,Marr N,Karim MY

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:Poor adherence to immunosuppressive treatment is common in patients with systemic lupus erythematosus and may identify those with lupus nephritis (LN) who have a poorer prognosis. Non-adherence has also been reported to be a potential adverse outcome predictor in renal transplantation (rTp). We investigated ...

journal_title：Lupus

authors： Ntatsaki E,Vassiliou VS,Velo-Garcia A,Salama AD,Isenberg DA

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:Further prospective study is needed to elucidate the etiology and natural history of systemic lupus erythematosus development. The clinical complexity of this heterogeneous disease makes study design challenging. Our objective was to ascertain useful screening factors for identifying at-risk individuals for f...

journal_title：Lupus

authors： Young KA,Munroe ME,Guthridge JM,Kamen DL,Gilkensen GS,Harley JB,Weisman MH,Karp DR,Wallace DJ,James JA,Norris JM

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:The objective of this paper is to assess the role of gender on survival rate and causes of death and organ damage in systemic lupus erythematosus (SLE) patients in China from 2009 to 2015. METHODS:We conducted a multicenter cohort study to analyze the differences in outcome data between male and female SLE p...

journal_title：Lupus

authors： Zhang S,Ye Z,Li C,Li Z,Li X,Wu L,Liu S,Zuo X,Zhu P,Wang Z,Wang Y,Wang Z,Zhao J,Wang Q,Tian X,Li M,Zeng X

更新日期：2019-04-01 00:00:00

abstract：:Organizing pneumonia is an inflammatory lung entity that presents with a huge variety of clinical, radiological and pathological patterns. Organizing pneumonia can be idiopathic or secondary to other diseases. Corticosteroid therapy is usually the first-line treatment showing clinical improvement in most cases. This r...

journal_title：Lupus

authors： Giménez AR,Pastrana DB,Huaranga MAR,Izquierdo JR,Cabrera B,García AN,Rodríguez CCR

更新日期：2019-04-01 00:00:00

abstract：:Cytomegalovirus (CMV) is particularly dangerous in systemic lupus erythematosus (SLE), being a problem both for the differential diagnosis with disease flare and for the management of SLE flare with immunosuppressive drugs. We report on four cases of SLE with concomitant CMV infection, having some common clinical and ...

journal_title：Lupus

authors： Sebastiani GD,Iuliano A,Canofari C,Bracci M

更新日期：2019-03-01 00:00:00

abstract：:Renal involvement is one of the main complications of systemic lupus erythematosus, causing a significant impact on patients' morbidity and mortality. Renal biopsy is still the gold standard of diagnosis, but it has many limitations. In this sense, several recent studies aim to identify biomarkers that not only predic...

journal_title：Lupus

authors： Gasparin AA,Pamplona Bueno de Andrade N,Hax V,Tres GL,Veronese FV,Monticielo OA

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:Anti-α-enolase antibody (Ab) combined with β2 microglobulin (β2-MG) were investigated to predict the incidence of nephritis in systemic lupus erythematosus (SLE) patients. METHODS:Levels of serum anti-α-enolase Ab and urinary β2-MG were detected in 115 SLE patients, 29 SLE patients with nephritis and 70 heal...

journal_title：Lupus

authors： Huang Y,Chen L,Chen K,Huang F,Feng Y,Xu Z,Wang W

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Antibodies to M-type phospholipase A2 receptor (a-PLA2R) have been identified in most patients with idiopathic membranous nephropathy, but the prevalence in membranous lupus nephritis (MLN) is still unclear. The objective of this study was to assess the prevalence of a-PLA2R antibodies in a large cohort of p...

journal_title：Lupus

authors： Garcia-Vives E,Solé C,Moliné T,Alvarez-Rios AM,Vidal M,Agraz I,Ordi-Ros J,Cortés-Hernández J

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:We sought to describe characteristics of children admitted with pericardial effusion (PCE) and systemic lupus erythematosus (SLE) and determine the association between PCE and outcomes of interest. METHODS:We performed a retrospective cohort study of the Pediatric Health Information System (PHIS). Patients w...

journal_title：Lupus

authors： Dalby ST,Tang X,Daily JA,Sukumaran S,Collins RT,Bolin EH

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:We analyzed data of lupus nephritis (LN) patients to find parameters that can predict remission. METHODS:Sixty-four LN patients who were diagnosed with class III, IV, V or V + III/IV by renal biopsy and were followed up for more than six months in our center were enrolled retrospectively. Receiver operating ...

journal_title：Lupus

authors： Liu G,Wang H,Le J,Lan L,Xu Y,Yang Y,Chen J,Han F

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:The aim of our study was to investigate the efficacy of adipose-derived stem cells (ADSC) transplantation in systemic lupus erythematosus (SLE) and to determine the mechanism of ADSC transplantation. METHODS:B6.MRL/lpr mice were administered ADSC intravenously every week from age 28 to 31 weeks, while the lu...

journal_title：Lupus

authors： Wei S,Xie S,Yang Z,Peng X,Gong L,Zhao K,Zeng K,Lai K

更新日期：2019-02-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disorder that can affect virtually any organ. Chylous ascites as a presenting manifestation of SLE has been described in a handful of cases in adults. However, to the best of our knowledge this presentation has never been reported in the pediatric age group. Podocyto...

journal_title：Lupus

authors： Pilania RK,Jindal AK,Sandesh G,Vignesh P,Suri D,Nada R,Singh S

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:We compared the 1997 update of the 1982 American College of Rheumatology (ACR-97) and the 2012 Systemic Lupus International Collaborating Clinics (SLICC-12) criteria, for earlier classification of systemic lupus erythematosus (SLE) in a multiethnic urban Asian SLE population. METHODS:Patients from a retrospe...

journal_title：Lupus

authors： Low ESH,Krishnaswamy G,Thumboo J

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and life-threatening condition with poor prognosis in patients with antiphospholipid syndrome (APS). Pulmonary thromboendarterectomy (PTE) is the optimal surgical option for CTEPH. OBJECTIVES:This retrospective cohort study aimed to evaluate th...

journal_title：Lupus

authors： Li C,Zhao J,Liu S,Song W,Zhu J,Hua L,Wang Q,Li M,Zeng X,Zhao Y

更新日期：2018-12-01 00:00:00

abstract：:Corrigendum to A North American perspective of content and quality of websites in the English language on childhood-onset lupus erythematosus by C Cutler et al. Published in Lupus (2018) 27, 762-770. DOI: 10.1177/0961203317746246 . The authors wish to highlight the following correction. The subheading in Table 5 shoul...

journal_title：Lupus

authors：

更新日期：2018-12-01 00:00:00

abstract：:The importance of the immunomodulatory effects of vitamin D has recently been associated with autoimmune and chronic inflammatory diseases. Vitamin D deficiency has been linked to the development of autoimmune conditions. Antiphospholipid syndrome is an autoimmune disease characterized by thrombotic events and obstetr...

journal_title：Lupus

authors： García-Carrasco M,Jiménez-Herrera EA,Gálvez-Romero JL,Mendoza-Pinto C,Méndez-Martínez S,Etchegaray-Morales I,Munguía-Realpozo P,Vázquez de Lara-Cisneros L,Santa Cruz FJ,Cervera R

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Palisaded neutrophilic and granulomatous dermatitis (PNGD) is a commonly occurring condition related to systemic autoimmune disease. It is characterized histopathologically by a distinct pattern of granulomatous inflammation in the presence or absence of leukocytoclastic vasculitis. The properties of granulo...

journal_title：Lupus

authors： Terai S,Ueda-Hayakawa I,Nguyen CTH,Ly NTM,Yamazaki F,Kambe N,Son Y,Okamoto H

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Polyarthritis is common to both mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE). Apart from being erosive and deforming in the former, we speculated that it was more common and the extent of joints involved would be higher in MCTD. METHODS:This was a cross-sectional study that ...

journal_title：Lupus

authors： Gunashekar S,Prakash M,Minz RW,Sharma A,Sharma S,Dhir V

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:There is no report about the association between GATA3 rs3824662 polymorphism and systemic lupus erythematosus (SLE). OBJECTIVE:To investigate the possible role of GATA3 rs3824662 polymorphism as a susceptibility risk factor for either adult SLE (aSLE) or pediatric SLE (pSLE) and to evaluate its role in the...

journal_title：Lupus

authors： Mosaad YM,Hammad A,Elghzaly AA,Tawhid ZME,Hammad EM,Showma A,Abdelsalam R,Elmoughy A,Fawzy IM,Anber N

更新日期：2018-11-01 00:00:00

abstract：:Objective Adherence to medication has a major impact on treatment control and success especially in chronic diseases but often remains unrecognized. Besides clinical, socioeconomic, disease-related and treatment-related parameters, general and personal health beliefs, as well as perception of health, can affect adhere...

journal_title：Lupus

authors： Chehab G,Sauer GM,Richter JG,Brinks R,Willers R,Fischer-Betz R,Winkler-Rohlfing B,Schneider M

更新日期：2018-09-01 00:00:00

abstract：:Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura (ITP), there are few data on the safety and efficacy of these medications in patients with concurrent systemic lupus erythematosus (SLE) or an...

journal_title：Lupus

authors： Lusa A,Carlson A

更新日期：2018-09-01 00:00:00

abstract：:Objectives Avascular necrosis (AVN) is one of the most common causes of organ damage in patients with systemic lupus erythematosus (SLE) and often causes serious physical disability. The aims of this study were to investigate clinical risk factors associated with symptomatic AVN and to analyze their synergistic effect...

journal_title：Lupus

authors： Kwon HH,Bang SY,Won S,Park Y,Yi JH,Joo YB,Lee HS,Bae SC

更新日期：2018-09-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) can affect all heart structures including the conduction system, with either reversible or permanent derangement. However, only a few cases of adult SLE and complete atrioventricular (AV) block have been reported. We describe a young pregnant woman who initially presented with comple...

journal_title：Lupus

authors： Lo CH,Wei JCC,Tsai CF,Li LC,Huang SW,Su CH

更新日期：2018-09-01 00:00:00

abstract：:Objective The objective of this study was to describe the clinical and immunological pattern and disease outcome in Egyptian systemic lupus erythematosus patients. Patients and methods The medical records of 770 systemic lupus erythematosus patients who were followed from 2002-2015 at Kasr Alainy Hospital, Cairo Unive...

journal_title：Lupus

authors： Mahmoud GA,Shahin AA,Zayed HS,Moghazy A,Eissa BM

更新日期：2018-08-01 00:00:00

abstract：:Neurological involvement in antiphospholipid antibody syndrome (APS) is common, and its occurrence increases morbidity and mortality. Patients may present variable neurological involvement, such as cerebrovascular disease, cognitive dysfunction, headache, seizures, movement disorders, multiple sclerosis-like syndrome,...

journal_title：Lupus

authors： Ricarte IF,Dutra LA,Abrantes FF,Toso FF,Barsottini OGP,Silva GS,de Souza AWS,Andrade D

更新日期：2018-08-01 00:00:00

abstract：:Background Patients with systemic lupus erythematosus (SLE) may form clusters with clinical manifestations and autoantibodies. Objective The objective of this report is to study whether SLE patients with positive rheumatoid factor (RF) have a special clinical and/or serological profile. Methods A retrospective study o...

journal_title：Lupus

authors： Fedrigo A,Dos Santos TAFG,Nisihara R,Skare T

更新日期：2018-07-01 00:00:00

abstract：:Tubulointerstitial injury is found frequently in lupus nephritis. Immune complex deposits can occur in the tubular basement membranes (TBMs), although its significance in lupus nephritis patients remains unclear. This study assessed the clinical and prognostic features of lupus nephritis patients with TBM deposits in ...

journal_title：Lupus

authors： Wang H,Xu J,Zhang X,Ren YL,Cheng M,Guo ZL,Zhang JC,Cheng H,Xing GL,Wang SX,Yu F,Zhao MH

更新日期：2018-04-01 00:00:00

abstract：:Objective The objective of this article is to examine the quality, content, and readability of information and resources in the English language and accessible on the internet by pediatric patients with systemic lupus erythematosus (SLE) and their families in North America. Methods Keywords relevant to SLE were genera...

journal_title：Lupus

authors： Cutler C,Peng T,Stinson J,Tucker L,Boneparth A,Klein Gitelman M,Moorthy LN

更新日期：2018-04-01 00:00:00

abstract：:Background Antimalarials (AMs) are widely used in the treatment of connective tissue diseases. Their main side effect is retinal damage, while heart disease has been described in isolated cases. The aim of this study is to systematically review the existing literature on AM-induced cardiomyopathy (AMIC). Methods The P...

journal_title：Lupus

authors： Tselios K,Deeb M,Gladman DD,Harvey P,Urowitz MB

更新日期：2018-04-01 00:00:00

abstract：:Objectives The aim of this study was to study the relationship between immunosuppressive drug treatment and survival in patients with systemic lupus erythematosus (SLE). Methods Patients who fulfilled four or more American College of Rheumatology criteria for SLE were followed longitudinally. Clinical characteristics,...

journal_title：Lupus

authors： Mok CC,Tse SM,Chan KL,Ho LY

更新日期：2018-04-01 00:00:00

abstract：:Objective The objective of this paper is to identify the risk of complications of real-time ultrasound-guided renal biopsy in adult and pediatric patients with systemic lupus erythematosus (SLE). Materials and methods This retrospective study examined outcomes of 296 renal biopsy procedures in 275 SLE patients. Imagin...

journal_title：Lupus

authors： Sun YS,Sun IT,Wang HK,Yang AH,Tsai CY,Huang CJ,Huang DF,Lai CC

更新日期：2018-04-01 00:00:00

abstract：:The complement system contributes to the pathogenesis of systemic lupus erythematosus (SLE). Mannose-binding lectin (MBL) is a key molecule of the lectin pathway of complement and seems to be related to the clinical manifestations of this disease. We evaluated the serum levels of MBL and its relationship with disease ...

journal_title：Lupus

authors： Cieslinski JZ,Skare TL,Nisihara R,De Messias-Reason IJ,Utiyama SRR

更新日期：2018-03-01 00:00:00

abstract：:Objective The main aim of this study was to investigate the ovarian reserve, menstruation, and lymphocyte subpopulation in systemic lupus erythematosus (SLE) patients of childbearing age. Methods We enrolled 40 SLE patients of childbearing age and 40 age-matched healthy controls. Anti-Müllerian hormone (AMH) was teste...

journal_title：Lupus

authors： Gao H,Ma J,Wang X,Lv T,Liu J,Ren Y,Li Y,Zhang Y

更新日期：2018-03-01 00:00:00

abstract：:Introduction White matter hyperintense (WMHI) lesions are the most common finding in magnetic resonance imaging (MRI) of the brain in patients with systemic lupus erythematosus (SLE). Objective The objective of this article is to determine the clinical factors associated with an increase in WMHI lesion load among SLE ...

journal_title：Lupus

authors： Shaharir SS,Osman SS,Md Rani SA,Sakthiswary R,Said MSM

更新日期：2018-01-01 00:00:00

abstract：:Objective The objective of this report is to evaluate the prevalence and clinico-serological correlations of anti-α-enolase antibody (Ab) in patients with systemic lupus erythematosus (SLE). Methods Thirty-two untreated patients with SLE and 20 age- and sex-matched healthy controls were evaluated by rheumatologic exam...

journal_title：Lupus

authors： Li M,Li J,Wang J,Li Y,Yang P

更新日期：2018-01-01 00:00:00

abstract：:Objective Several studies have evaluated the prevalence of rheumatoid factor (RF) and anti-citrullinated proteins antibodies (ACPA) in systemic lupus erythematosus (SLE) patients but no data are available on the anti-carbamylated proteins (anti-CarP), a new biomarker for rheumatoid arthritis (RA). We evaluated the ant...

journal_title：Lupus

authors： Massaro L,Ceccarelli F,Colasanti T,Pendolino M,Perricone C,Cipriano E,Natalucci F,Capalbo G,Lucchetti R,Pecani A,Vomero M,Mancini R,Spinelli FR,Alessandri C,Valesini G,Conti F

更新日期：2018-01-01 00:00:00

abstract：:Objective Genetic variants in FH (complement factor H) were reported to associate with susceptibility to systemic lupus erythematosus (SLE). This study proposed that the genetic defects of FH in the susceptibility and in the development of lupus nephritis might be different. Methods This study enrolled 334 lupus nephr...

journal_title：Lupus

authors： Tan M,Hao JB,Chu H,Wang FM,Song D,Zhu L,Yu F,Li YZ,Song Y,Zhao MH

更新日期：2017-10-01 00:00:00

abstract：:Objectives We analyzed the clinical follow-up results of 88 lupus nephritis patients to find prognostic factors for the development of chronic kidney disease in ethnically homogeneous Korean patients with biopsy-proven lupus nephritis. Methods Sociodemographic, clinical, laboratory, and treatment-related data at the t...

journal_title：Lupus

authors： Park DJ,Kang JH,Lee JW,Lee KE,Kim TJ,Park YW,Lee JS,Choi YD,Lee SS

更新日期：2017-10-01 00:00:00

abstract：:Background and objective African-Americans and Hispanic-Americans with lupus are the two most common minority groups who receive kidney transplants in the USA. It is unknown if African-Americans and Hispanic-Americans with lupus have similar outcomes after kidney transplantation. In this study, we assessed whether Afr...

journal_title：Lupus

authors： Gonzalez-Suarez ML,Contreras G

更新日期：2017-10-01 00:00:00